Reviewer Name: Date: Manuscript Title: Manuscript ID:

1. Introduction & Rationale

Does the manuscript clearly define the research question/objective? Yes No Partial Comments:

2. Methods

Item	Yes	No	Partial
Eligibility criteria are clearly described
Information sources are reported
Search strategy is adequately described
Study selection process is explained
Data extraction methods are stated
Risk of bias assessment is reported

Comments:

3. Results

Are the study selection and characteristics adequately presented? Yes No Partial Are results of individual studies clearly reported? Yes No Partial Comments:

4. Discussion & Conclusions

Are the findings interpreted appropriately? Yes No Partial Are limitations discussed? Yes No Partial Comments:

5. Overall Assessment

Overall quality of the systematic review manuscript: Excellent Good Fair Poor General Comments / Recommendations: